METABOLITES OF THE HIGHER FUNGI .26. CUBENSIC ACID, 3,7,11,15-TETRAHYDROXY-18-(HYDROXYMETHYL)-2,4,6,10,14,16,20-HEPTAMETHYLDOCOSA-4E,8E,12E,16E-TETRAENOIC ACID, A NOVEL POLYSUBSTITUTED C22 FATTY-ACID FROM THE FUNGUS XYLARIA-CUBENSIS (MONT) FR WITH SUBSTITUENTS AND SUBSTITUTION PATTERN SIMILAR TO THE MACROLIDE ANTIBIOTICS

被引:23
作者
EDWARDS, RL [1 ]
MAITLAND, DJ [1 ]
WHALLEY, AJS [1 ]
机构
[1] LIVERPOOL POLYTECH,DEPT BIOL,LIVERPOOL L3 3AF,ENGLAND
来源
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1991年 / 06期
关键词
D O I
10.1039/p19910001411
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Cubensic acid, 3,7,11,15-tetrahydroxy-18-(hydroxymethyl)-2,4,6,10,14,16,20 ?? -heptamethyldocosa-4E,8E,12E,16E-tetraenoic acid, has been isolated from the mycelium and culture medium of Xylaria cubensis. Cytochalasin D is an additional metabolite isolated from the culture medium. The structure of cubensic acid has been determined by a combination of spectroscopic and chemical methods. A possible biosynthetic link between cubensic acid and certain macrolide antibiotics is suggested.
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页码:1411 / &
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