MECHANISMS INVOLVED IN STIMULATION OF INSULIN-SECRETION BY THE HYPOGLYCEMIC ALPHA-ADRENERGIC ANTAGONIST, DG-5128

被引：24

作者：

CHAN, SLF ^{[1
]}

STILLINGS, MR ^{[1
]}

MORGAN, NG ^{[1
]}

机构：

[1] RECKITT & COLMAN PLC, Kingston Upon Hull HU8 7DS, ENGLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 176卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0006-291X(91)90463-H

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The selective α2-antagonist DG-5128 provoked a dose-dependent stimulation of insulin release from isolated rat islets. DG-5128 was only weakly effective as an antagonist of noradrenaline-induced inhibition of insulin secretion but, surprisingly, was able to reverse the suppression of secretion and increase in 86Rb efflux from preloaded islets, mediated by diazoxide. These effects were not reproduced with more effective α-antagonists, suggesting that stimulation of insulin secretion by DG-5128 is independent of α-receptor blockade. © 1991.

引用

页码：1545 / 1551

页数：7

共 27 条

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