ALPHA-MELANOCYTE-STIMULATING HORMONE REDUCES INTERLEUKIN-1-BETA EFFECTS ON RAT STOMACH PREPARATIONS POSSIBLY THROUGH INTERFERENCE WITH A TYPE-I RECEPTOR

被引：59

作者：

MUGRIDGE, KG

PERRETTI, M

GHIARA, P

PARENTE, L

机构：

[1] Scflvo Research Centre, 53100 Siena, Via Fiorentina I

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 197卷 / 2-3期

关键词：

INTERLEUKIN-1; ALPHA-MELANOCYTE-STIMULATING HORMONE (ALPHA-MSH); STOMACH STRIP (RAT); IL-1-BETA RECEPTORS;

D O I：

10.1016/0014-2999(91)90514-Q

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Contractions elicited by CaCl2 on isolated rat stomach strip preparations have been reported to be potentiated by interleukin-1-beta (IL-1-beta). We have investigated whether this effect can be reduced by the putative IL-1-beta antagonist, alpha-melanocyte-stimulating hormone (alpha-MSH). Additionally, the effects of alpha-MSH on the specific binding of IL-1-beta to B- and T-cells have been investigated to further clarify its inhibitory activities. Both alpha-MSH and its carboxyl terminal tripeptide concentration dependently reduced the potentiation of CaCl2-induced contractions caused by IL-1-beta but not those caused by leukotriene D4, the parent molecule being approximately 250 times more active. Additionally, both peptides potently and selectively reduced I-125-IL-1-beta binding to the T-cell sub-clone EL4-6.1 but not to the B-cell sub-clone 1H7. The results indicate that IL-1-beta effects on rat stomach may be mediated through a type-I (80 kDa) IL-1-beta receptor.

引用

页码：151 / 155

页数：5

共 20 条

[1] EVIDENCE FOR DIFFERENT INTERLEUKIN-1 RECEPTORS IN MURINE B-CELL AND T-CELL LINES
BOMSZTYK, K
SIMS, JE
STANTON, TH
SLACK, J
MCMAHAN, CJ
VALENTINE, MA
DOWER, SK
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (20) : 8034 - 8038
[2] CANNON JG, 1986, J IMMUNOL, V137, P2232
[3] 2 HIGH-AFFINITY INTERLEUKIN-1 RECEPTORS REPRESENT SEPARATE GENE-PRODUCTS
CHIZZONITE, R
TRUITT, T
KILIAN, PL
STERN, AS
NUNES, P
PARKER, KP
KAFFKA, KL
CHUA, AO
LUGG, DK
GUBLER, U
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (20) : 8029 - 8033
[4] ANALYSIS OF THE ANTIPYRETIC ACTION OF ALPHA-MELANOCYTE-STIMULATING HORMONE IN RABBITS
CLARK, WG
HOLDEMAN, M
LIPTON, JM
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1985, 359 (FEB): : 459 - 465
[5] INTERLEUKIN-1 (IL-1) GENE-EXPRESSION, SYNTHESIS, AND EFFECT OF SPECIFIC IL-1 RECEPTOR BLOCKADE IN RABBIT IMMUNE-COMPLEX COLITIS
COMINELLI, F
NAST, CC
CLARK, BD
SCHINDLER, R
LLERENA, R
EYSSELEIN, VE
THOMPSON, RC
DINARELLO, CA
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1990, 86 (03) : 972 - 980
[6] DAYNES RA, 1987, J IMMUNOL, V139, P103
[7] INHIBITION BY NEUROPEPTIDES OF INTERLEUKIN-1-BETA-INDUCED, PROSTAGLANDIN-INDEPENDENT HYPERALGESIA
FOLLENFANT, RL
NAKAMURACRAIG, M
HENDERSON, B
HIGGS, GA
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1989, 98 (01) : 41 - 43
[8] HYPOTHERMIC AND ANTI-PYRETIC EFFECTS OF CENTRALLY ADMINISTERED ACTH (1-24) AND ALPHA-MELANOTROPIN
GLYN, JR
LIPTON, JM
[J]. PEPTIDES, 1981, 2 (02) : 177 - 187
[9] ALPHA-MSH INJECTED INTO THE SEPTAL REGION REDUCES FEVER IN RABBITS
GLYNBALLINGER, JR
BERNARDINI, GL
LIPTON, JM
[J]. PEPTIDES, 1983, 4 (02) : 199 - 203
[10] ANTIINFLAMMATORY ACTIVITY OF A COOH-TERMINAL FRAGMENT OF THE NEUROPEPTIDE ALPHA-MSH
HILTZ, ME
LIPTON, JM
[J]. FASEB JOURNAL, 1989, 3 (11) : 2282 - 2284

← 1 2 →