BREFELDIN-A INHIBITS PROTEIN-SYNTHESIS THROUGH THE PHOSPHORYLATION OF THE ALPHA-SUBUNIT OF EUKARYOTIC INITIATION FACTOR-II

被引：15

作者：

MELLOR, H ^{[1
]}

KIMBALL, SR ^{[1
]}

JEFFERSON, LS ^{[1
]}

机构：

[1] PENN STATE UNIV,COLL MED,DEPT CELLULAR & MOLEC PHYSIOL,HERSHEY,PA 17033

来源：

FEBS LETTERS | 1994年 / 350卷 / 01期

关键词：

BREFELDIN A; PROTEIN SYNTHESIS; EIF-2; PROTEIN PHOSPHORYLATION;

D O I：

10.1016/0014-5793(94)00756-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Brefeldin A is a fungal metabolite which disrupts protein traffic through the Golgi apparatus and thereby inhibits protein secretion. Recently, it has been shown that Brefeldin A also causes a marked decrease in the rate of protein synthesis in cells in culture [1992, FEBS Lett. 314, 371-374]. We show here that treatment of rat GH3 pituitary cells with Brefeldin A leads to an inhibition of protein synthesis at the level of peptide-chain initiation through a mechanism involving the phosphorylation of the alpha-subunit of eukaryotic initiation factor-2 (eIF-2 alpha).

引用

页码：143 / 146

页数：4

共 22 条

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