The urinary concentration of sialic acid is increased in non-insulin-dependent diabetic patients with microangiopathy: A possible useful marker for diabetic microangiopathy

被引：6

作者：

Suzuki, K

Ishida, H

Sugimoto, C

Taguchi, Y

Matsuda, H

Nosaka, K

Someya, Y

Kadowaki, S

Seino, Y

机构：

[1] Department of Metabolism and Clinical Nutrition, Kyoto University School of Medicine, Kyoto

[2] Departments of Clinical Laboratory Medicine, Shimada Municipal Hospital, Shizuoka

[3] Departments of Internal Medicine, Shimada Municipal Hospital, Shizuoka

[4] Shimada Municipal Hospital, Shizuoka

[5] Division of Clinical Nutrition and Metabolism, Faculty of Health Science, Suzuka University of Medical Science and Technology, Mie

来源：

DIABETIC MEDICINE | 1995年 / 12卷 / 12期

关键词：

sialic acid; diabetic microangiopathy; glomerular basement membrane; retinopathy; nephropathy;

D O I：

10.1111/j.1464-5491.1995.tb00426.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In order to investigate the relationship between urinary excretion of sialic acid and the severity of diabetic microangiopathy, urinary levels of sialic acid were determined in patients with non-insulin-dependent diabetes mellitus. The urinary molar ratio of sialic acid to creatinine in the diabetic patients was significantly higher than in the healthy controls (p < 0.01). Moreover, the urinary ratio was found to be gradually increased with the degree of diabetic microangiopathy. Urine molar ratio of sialic acid to creatinine in patients with proliferative diabetic retinopathy was significantly higher than in patients without retinopathy (p < 0.01). Urinary excretion in patients with macroproteinuria was also significantly higher than in patients without nephropathy (p < 0.01). Since urinary levels of sialic acid are proportionally increased with the severity of diabetic microangiopathy, the measurement of urinary sialic acid could become a useful biochemical means to monitor the degree of diabetic microangiopathy.

引用

页码：1092 / 1096

页数：5

共 11 条

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