SUBCHRONIC TOXICITY STUDIES OF SALATRIM STRUCTURED TRIACYLGLYCEROLS IN RATS .2. TRIACYLGLYCEROLS COMPOSED OF STEARATE, ACETATE, AND PROPIONATE

SALATRIM 23CA lot A014, SALATRIM 32CA lot A015, and SALATRIM 23SO lot A026 are members of a family of structured triacylglycerols having caloric densities of 4.5-6.0 kcal/g. Rats received 0 %, 2 %, 5 % and 10 % of the first two SALATRIM fats or 10 % corn oil in the diet for 13 weeks. Body weight and feed consumption were unaffected. Minimally increased urinary phosphorus clearance occurred in 10 % SALATRIM groups. Bone mineral variations and an increased incidence of renal mineralization occurred in 10 % SALATRIM and corn oil fed rats. These changes appeared to be;directly related to the quantity of unsaturated fatty acids in the high-fat diets. Measurements of serum and liver fat-soluble vitamin concentrations, necropsy, clinical pathology, organ weights, and histopathology revealed no SALATRIM-related effects. Corn oil produced hepatocellular vacuolation. In a supplementary short-term study, 10 % dietary SALATRIM, 23SO lot A026 produced no effect on selected serum transaminases. Overall, the SALATRIM fats produced no toxicologically significant effects.