TREATMENT OF STEROID-RESISTANT POSTTRANSPLANT NEPHROTIC SYNDROME WITH CYCLOPHOSPHAMIDE IN A CHILD WITH CONGENITAL NEPHROTIC SYNDROME

被引：12

作者：

FLYNN, JT

SCHULMAN, SL

DECHADAREVIAN, JP

DUNN, SP

KAISER, BA

POLINSKY, MS

BALUARTE, HJ

机构：

[1] Department of Pediatrics, St. Christopher's Hospital for Children, Temple University School of Medicine, Philadelphia, 19134-1095, Pennsylvania, Erie Avenue at Front Street

[2] Department of Anatomic Pathology, St. Christopher's Hospital for Children, Temple University School of Medicine, Philadelphia, Pennsylvania

[3] Department of General Surgery, St. Christopher's Hospital for Children, Temple University School of Medicine, Philadelphia, Pennsylvania

来源：

PEDIATRIC NEPHROLOGY | 1992年 / 6卷 / 06期

关键词：

CONGENITAL NEPHROTIC SYNDROME; RENAL TRANSPLANT; CORTICOSTEROIDS; CYCLOPHOSPHAMIDE; POSTTRANSPLANT NEPHROTIC SYNDROME;

D O I：

10.1007/BF00866503

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A child with congenital nephrotic syndrome underwent renal transplantation, was treated for acute rejection, and then developed nephrotic syndrome and renal failure. He was felt to have minimal change disease on allograft biopsy, but failed to respond to therapy with corticosteroids. Cyclophosphamide was substituted for cyclosporine and rapidly induced a complete remission of his nephrotic syndrome. We feel that this case not only represents an important example of a useful therapeutic approach to the child with congenital nephrotic syndrome who develops nephrotic syndrome post transplantation, and also raises questions concerning the pathogenesis of congenital nephrotic syndrome.

引用

页码：553 / 555

页数：3

共 12 条

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