SOMATIC MUTATIONS OF VON HIPPEL-LINDAU (VHL) TUMOR-SUPPRESSOR GENE IN EUROPEAN KIDNEY CANCERS

被引：39

作者：

BAILLY, M

BAIN, C

FAVROT, MC

OZTURK, M

机构：

[1] CTR LEON BERARD, MOLEC ONCOL LAB, INSERM, CJF 9302, F-69373 LYON 08, FRANCE

[2] CTR LEON BERARD, BIOL CELLULAIRE LAB, F-69373 LYON 08, FRANCE

来源：

INTERNATIONAL JOURNAL OF CANCER | 1995年 / 63卷 / 05期

关键词：

D O I：

10.1002/ijc.2910630510

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Somatic mutations of von Hippel Lindou (VHL) tumor-suppressor gene have been identified in kidney cancers from North America and Japan. We studied VHL gene mutation in 31 kidney tumors from France. Of these tumors, 45% (14/31) displayed mutations, 60% of which occurred at A:T base pairs. The frequency and the spectrum of mutations identified in kidney tumors from Europe were similar to those reported for tumors from other geographical locations. (C) 1995 Wiley-Liss, Inc.

引用

页码：660 / 664

页数：5

共 21 条

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