MAMMARY-TUMOR SUPPRESSION BY TRANSFORMING GROWTH-FACTOR-BETA-1 TRANSGENE EXPRESSION

被引：260

作者：

PIERCE, DF

GORSKA, AE

CHYTIL, A

MEISE, KS

PAGE, DL

COFFEY, RJ

MOSES, HL

机构：

[1] VANDERBILT UNIV,SCH MED,DEPT CELL BIOL,NASHVILLE,TN 37232

[2] VANDERBILT UNIV,SCH MED,DEPT MED,NASHVILLE,TN 37232

[3] VANDERBILT UNIV,SCH MED,DEPT PATHOL & SURG,NASHVILLE,TN 37232

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 10期

关键词：

TRANSGENIC MICE; MOUSE MAMMARY TUMOR VIRUS; BREAST CANCER;

D O I：

10.1073/pnas.92.10.4254

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In cell culture, type alpha transforming growth factor (TGF-alpha) stimulates epithelial cell growth,whereas TGF-beta 1 overrides this stimulatory effect and is growth inhibitory. Transgenic mice that overexpress TGF-cu under control of the mouse mammary tumor virus (MMTV) promoter/enhancer exhibit mammary ductal hyperplasia and stochastic development of mammary carcinomas, a process that can be accelerated by administration of the chemical carcinogen 7,12-dimethylbenz[a]anthracene. MR4TV-TGF-beta 1 transgenic mice display mammary ductal hypoplasia and do not develop mammary tumors. We report that in crossbreeding experiments involving the production of mice carrying both the MMTV-TGF-beta 1 and MMTV-TGF-alpha transgenes, there is marked suppression of mammary tumor formation and that MMTV-TGF-beta 1 transgenic mice are resistant to 7,12-dimethylbenz [a] anthracene-induced mammary tumor formation. These data demonstrate that overexpression of TGF-beta 1 in vivo can markedly suppress mammary tumor development.

引用

页码：4254 / 4258

页数：5

共 38 条

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