REGIODEFINED SYNTHESIS AND CONFORMATIONAL PROPERTIES OF ADENYLDIYL TRIMERS WITH UNSYMMETRICAL 2'-5' AND 3'-5' INTERNUCLEOTIDE LINKAGES

被引：6

作者：

HAYAKAWA, Y ^{[1
]}

HIROSE, M ^{[1
]}

NOYORI, R ^{[1
]}

机构：

[1] NAGOYA UNIV,FAC SCI,DEPT CHEM,CHIKUSA KU,NAGOYA,AICHI 46401,JAPAN

来源：

TETRAHEDRON | 1995年 / 51卷 / 36期

关键词：

D O I：

10.1016/0040-4020(95)00590-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Adenyldiyl trimers with different kinds of substituents on 2'-5' and 3'-5' phosphate linkages have been synthesized in a general, regiodefined manner. Examination of the 2D NMR spectra reveals that the trimers with adenylyl(2'-5')adenosine linkage make a syn-anti as well as syn-syn base stack between the two adenyl bases and exist as a mixture of the two conformers.

引用

页码：9899 / 9916

页数：18

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