INCREASE OF EXTRACELLULAR INSULIN-LIKE GROWTH FACTOR-I (IGF-I) CONCENTRATION FOLLOWING ELECTROLYTICAL LESION IN RAT HIPPOCAMPUS

被引：42

作者：

YAMAGUCHI, F

ITANO, T

MIYAMOTO, O

JANJUA, NA

OHMOTO, T

HOSOKAWA, K

HATASE, O

机构：

[1] KAGAWA MED SCH,DEPT PHYSIOL,MIKI CHO,KITA,KAGAWA 76107,JAPAN

[2] KAGAWA MED SCH,DEPT NEUROPSYCHIAT,KAGAWA,JAPAN

[3] KAGAWA MED SCH,DEPT NEUROSURG,KAGAWA,JAPAN

来源：

NEUROSCIENCE LETTERS | 1991年 / 128卷 / 02期

关键词：

IGF-I; ELECTROLYTICAL LESION; INTRACEREBRAL MICRODIALYSIS; GFAP IMMUNOREACTIVITY; HIPPOCAMPUS;

D O I：

10.1016/0304-3940(91)90278-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The change of extracellular insulin-like growth factor I (IGF-I) level following electrolytical lesion in rat hippocampus was studied by intracerebral microdialysis technique. The microdialysis probes were inserted into the lesioned and normal side of hippocampus on the day and each week after making the lesion for a period of four weeks. The content of IGF-I in the dialysis perfusate was measured by a radioimmunoassay. One week after surgery, IGF-I level (mean +/- S.E.M.) increased from 235.6 +/- 25.4 pg/100-mu-l perfusate (day 0) to 305.5 +/- 15.6 pg/100-mu-l perfusate (day 7), and then decreased gradually. This suggests that there is accumulation or increase in secretion of IGF-I at the lesioned site, and that IGF-I might have an important role in vivo in the brain tissue recovery from damage.

引用

页码：273 / 276

页数：4

共 24 条

[1] INSULIN-LIKE GROWTH FACTOR-I (SOMATOMEDIN-C) RECEPTORS IN THE RAT-BRAIN - DISTRIBUTION AND INTERACTION WITH THE HIPPOCAMPAL CHOLINERGIC SYSTEM [J].