EFFECT OF IBUPROFEN ON THE HEALING AND REMODELING OF BONE AND ARTICULAR-CARTILAGE IN THE RABBIT TEMPOROMANDIBULAR-JOINT

被引：14

作者：

OBEID, G

XIEN, Z

XING, W

机构：

[1] BEIJING MED UNIV,SCH STOMATOL,DEPT ORAL & MAXILLOFACIAL SURG,BEIJING,PEOPLES R CHINA

[2] WASHINGTON HOSP CTR,DEPT ORAL & MAXILLOFACIAL SURG,RESIDENCY TRAINING PROGRAM,WASHINGTON,DC 20010

来源：

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | 1992年 / 50卷 / 08期

关键词：

D O I：

10.1016/0278-2391(92)90276-6

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

The purpose of this study was to determine the effect of ibuprofen on the healing and remodeling of bone and cartilage in the temporomandibular joint of the rabbit. Forty-two rabbits were operated on to create a groove and a hole in the articular surface of both the right and left mandibular condyles. Following surgery, the animals were divided into three groups. Group A (12 rabbits) was used as a control and the animals did not receive any medication. Group B (15 rabbits) was given a daily dose of 17 mg/kg of ibuprofen. Group C (15 rabbits) was given a daily dose of 34 mg/kg of ibuprofen. All animals were killed after 4 weeks. The 84 condyles were examined clinically and histologically. Statistical analysis showed a highly significant difference in the healing of bone and cartilage between groups A and C (P < .01) and a significant difference between groups A and B (P < .05). The results of this study indicate that ibuprofen has an adverse effect on the healing of bone and cartilage in the temporomandibular joint of the rabbit. © 1992.

引用

页码：843 / 849

页数：7

共 34 条

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[2]

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