ASSIGNMENT OF 4 SEQUENCE-TAGGED SITES TO 3 SUBREGIONS OF 13Q12 USING A SOMATIC-CELL HYBRID MAPPING PANEL

被引:8
作者
MICHALSKI, AJ [1 ]
COWELL, JK [1 ]
机构
[1] INST CHILD HLTH,ICRF,ONCOL UNIT,30 GUILFORD ST,LONDON WC1N 1EH,ENGLAND
关键词
D O I
10.1006/geno.1993.1439
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
To define the position of a 13q12 breakpoint from a patient with ganglioneuroblastoma, a series of somatic cell hybrids carrying human chromosome translocations with breakpoints in the proximal part of chromosome 13 has been compiled. Sequence-tagged sites (STS) have been generated from a series of Alu-PCR probes previously shown to be in the 13q12 region. Together with an STS for the oncogene FLT1, these have been used to define the relative positions of the translocation breakpoints in the hybrids. In this way, four markers have been ordered in three subregions of 13q12 and reference breakpoints established. The refined physical map of 13q12 provides a series of reference markers with known locations and will be invaluable in the further characterization of breakpoints in this region. © 1993 Academic Press, Inc.
引用
收藏
页码:141 / 143
页数:3
相关论文
共 10 条
[1]   DEVELOPMENT OF HUMAN CHROMOSOME-SPECIFIC PCR PRIMERS FOR CHARACTERIZATION OF SOMATIC-CELL HYBRIDS [J].
ABBOTT, C ;
POVEY, S .
GENOMICS, 1991, 9 (01) :73-77
[2]   A CONTIGUOUS LINKAGE MAP OF CHROMOSOME-13Q WITH 39 DISTINCT LOCI SEPARATED ON AVERAGE BY 5.1 CENTIMORGANS [J].
BOWCOCK, AM ;
FARRER, LA ;
HEBERT, JM ;
BALE, AE ;
CAVALLISFORZA, L .
GENOMICS, 1991, 11 (03) :517-529
[3]   GENERATION OF NOVEL SEQUENCE TAGGED SITES (STSS) FROM DISCRETE CHROMOSOMAL REGIONS USING ALU-PCR [J].
COLE, CG ;
GOODFELLOW, PN ;
BOBROW, M ;
BENTLEY, DR .
GENOMICS, 1991, 10 (03) :816-826
[4]   RAPID ISOLATION OF HUMAN CHROMOSOME-SPECIFIC DNA PROBES FROM A SOMATIC-CELL HYBRID [J].
COTTER, FE ;
HAMPTON, GM ;
NASIPURI, S ;
BODMER, WF ;
YOUNG, BD .
GENOMICS, 1990, 7 (02) :257-263
[5]  
COWELL JK, 1992, HUMAN CYTOGENETICS P, V9, P235
[6]  
COWELL JK, 1989, OPHTHAL PED GENET, V110, P117
[7]  
HOGG A, 1992, ONCOGENE, V7, P1444
[8]  
MICHALSKI AJ, 1992, ONCOGENE, V7, P1595
[9]   REGIONAL ASSIGNMENT OF THE STEROID SULFATASE-X-LINKED ICHTHYOSIS LOCUS - IMPLICATIONS FOR A NON-INACTIVATED REGION ON THE SHORT ARM OF HUMAN X-CHROMOSOME [J].
MOHANDAS, T ;
SHAPIRO, LJ ;
SPARKES, RS ;
SPARKES, MC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (11) :5779-5783
[10]  
ROSNET O, 1993, ONCOGENE, V8, P173