C-TERMINAL PHOSPHORYLATION OF HUMAN RESPIRATORY SYNCYTIAL VIRUS P-PROTEIN OCCURS MAINLY AT SERINE RESIDUE-232

被引：40

作者：

SANCHEZSECO, MP ^{[1
]}

NAVARRO, J ^{[1
]}

MARTINEZ, R ^{[1
]}

VILLANUEVA, N ^{[1
]}

机构：

[1] INST SALUD CARLOS 3, CTR NACL MICRBIOL VIROL & IMMUNOL SANITARIAS, SERV VIROL, E-28220 MAJADAHONDA, SPAIN

来源：

JOURNAL OF GENERAL VIROLOGY | 1995年 / 76卷

关键词：

D O I：

10.1099/0022-1317-76-2-425

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

To determine which human respiratory syncytial virus (HRSV) P protein serine residues are modified by cellular protein kinase(s), several mutated versions of P protein were expressed in the absence of other viral proteins. Mutations at serines 232 or 232 and 237 drastically reduced the extent of phosphorylation P protein in vivo. Serine 232 is the main site of modification and is also essential for in vitro phosphorylation by casein kinase II. Additional in vivo phosphorylation was also detected in the region containing serines 116, 117 and 119.

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页码：425 / 430

页数：6

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