COLONIC PROTEOLYSIS FOLLOWING PANCREATIC DUCT LIGATION IN THE RAT

被引：8

作者：

BUSTOS, D ^{[1
]}

TISCORNIA, O ^{[1
]}

CALDARINI, MI ^{[1
]}

NEGRI, G ^{[1
]}

PONS, S ^{[1
]}

OGAWA, K ^{[1
]}

DEPAULA, JA ^{[1
]}

机构：

[1] INST GASTROENTEROL DR JORGE PEREZ COMPANC, BUENOS AIRES, ARGENTINA

来源：

INTERNATIONAL JOURNAL OF PANCREATOLOGY | 1994年 / 16卷 / 01期

关键词：

PROTEOLYSIS; PANCREATIC PROTEASE; TRYPSIN; CHYMOTRYPSIN; LARGE BOWEL;

D O I：

10.1007/BF02925609

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Luminal proteolytic activity (PA) of different colonic segments was ascertained in animals subjected to pancreatic duct ligation (PDL) and in control rats. The PDL rats revealed a significant PA reduction in the cecum, proximal colon (P < 0.01), and distal colon (P < 0.05). Proteolytic activity, trypsin, and chymotrypsin activity in control rats diminished progressively from the cecum to the distal colon. Conversely in PDL rats, we found maximal PA in distal colon. The conclusion is drawn that a significant proportion of colonic proteolytic activity can be attributed to pancreatic proteases with a maximal contribution at cecum level.

引用

页码：45 / 49

页数：5

共 19 条

[1] DETERMINATION OF IMMUNOREACTIVE TRYPSIN, PANCREATIC ELASTASE AND CHYMOTRYPSIN IN EXTRACTS OF HUMAN FECES AND ILEOSTOMY DRAINAGE [J].

BOHE, M ;

BORGSTROM, A ;

GENELL, S ;

OHLSSON, K .

DIGESTION, 1983, 27 (01) :8-15

[2]

BOUNOUS G, 1977, GASTROENTEROLOGY, V73, P102

[3]

BOUNOUS G, 1965, ARCH SURG-CHICAGO, V91, P371

[4] PROTEOLYTIC ACTIVITY OF RUMEN MICROORGANISMS AND EFFECTS OF PROTEINASE-INHIBITORS [J].

BROCK, FM ;

FORSBERG, CW ;

BUCHANANSMITH, JG .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1982, 44 (03) :561-569

[5] SENSITIVE NEW SUBSTRATE FOR CHYMOTRYPSIN [J].

DELMAR, EG ;

LARGMAN, C ;

BRODRICK, JW ;

GEOKAS, MC .

ANALYTICAL BIOCHEMISTRY, 1979, 99 (02) :316-320

[6] PREPARATION AND PROPERTIES OF 2 NEW CHROMOGENIC SUBSTRATES OF TRYPSIN [J].

ERLANGER, BF ;

COHEN, W ;

KOKOWSKY, N .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1961, 95 (02) :271-&

[7] IMMUNOCHEMICAL QUANTITATION OF PANCREATIC ENDOPEPTIDASES IN INTESTINAL CONTENTS OF GERMFREE AND CONVENTIONAL RATS [J].

GENELL, S ;

GUSTAFSSON, BE ;

OHLSSON, K .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1977, 12 (07) :811-820

[8]

GENELL S, 1976, SCAND J GASTROENTERO, V11, P757

[9]

HARSCHILD AHW, 1985, J BACTERIOL, V29, P1019

[10]

KUKNAL J, 1965, SURGERY, V162, P67

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