STRATEGIES FOR DATABASE DEREPLICATION OF NATURAL-PRODUCTS

The rapid characterization of known compounds (dereplication) has become an important consideration for the natural products chemise screening for pharmaceutical or agricultural compounds. Several commercial databases have been developed to assist the chemist in identifying known compounds with minimal amounts of physical or biological data. Strategies have been developed to efficiently search STN (Scientific and Technical Network) files with formula weight, carbon count, structure fragments, bioactivity, and taxonomy. A brief review is also provided on other commercially available databases that are useful for natural products dereplication.