NITRIC-OXIDE - A SYNCHRONIZING CHEMICAL MESSENGER

被引：54

作者：

ANBAR, M

机构：

[1] Department of Biophysical Sciences, School of Medicine and Biomedical Sciences, SUNY, Buffalo, 14214, New York

来源：

EXPERIENTIA | 1995年 / 51卷 / 06期

关键词：

NITRIC OXIDE; CHEMICAL MESSENGER; AUTOCATALYSIS; METALLO-ENZYMES; INTRACELLULAR SYNCHRONIZATION; ANAEROBIC MICROORGANISMS; EVOLUTION OF EUKARYOTES; CHEMICAL EVOLUTION;

D O I：

10.1007/BF02128740

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nitric oxide (NO) has been recognized as a ubiquitous chemical messenger in a large number of different biological systems. Its chemical properties make it less specific and less controllable than practically any other neurotransmitter or hormone. In view of this, its extensive biological role as a chemical messenger seems surprising. It is suggested that the biological function of NO evolved early in the anaerobic stage of evolution. In view of its low molecular weight, limited interaction with water, and its electrical neutrality, which allow it to diffuse rapidly through the cytoplasm and biomembranes, it is suggested that the need for NO has been retained by and maintained in eukaryote cells because of its ability to affect many biochemical functions simultaneously, acting primarily as an intracellular synchronizing chemical messenger.

引用

页码：545 / 550

页数：6

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