BENZOYL PEROXIDE ACTS AS A PROMOTER OF RADIATION-INDUCED MALIGNANT TRANSFORMATION IN-VITRO

被引：14

作者：

KENNEDY, SH ^{[1
]}

MANEVICH, Y ^{[1
]}

BIAGLOW, J ^{[1
]}

机构：

[1] UNIV PENN,DEPT RADIAT ONCOL,PHILADELPHIA,PA 19104

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 212卷 / 01期

关键词：

D O I：

10.1006/bbrc.1995.1944

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The experiments reported here demonstrate that benzoyl peroxide (BP) can promote radiation induced transformation in vitro. BP is shown to be capable of generating free radicals, determined by the kinetics of hydroxylation as measured by fluorescence of coumarin-3-carboxylic acid. Although the mechanisms involved in the BP enhancement of radiation transformation are unknown, we hypothesize that lipid peroxidation produced by benzoyl radicals in the vicinity of membrane associated unsaturated lipids could contribute to the promotion of transformation in vitro. (C) 1995 Academic Press. Inc.

引用

页码：118 / 125

页数：8

共 26 条

[1]

ALBERT RE, 416933170 US AT EN C

[2] INDUCTION OF INVITRO TRANSFORMATION BY NEAR-UV LIGHT AND ITS INTERACTION WITH BETA-PROPIOLACTONE [J].