A ROLE OF EXCITATORY AMINO-ACIDS IN THE ACTIVATION OF LOCUS-CERULEUS NEURONS FOLLOWING CUTANEOUS THERMAL STIMULI

被引：29

作者：

HAJOS, M ^{[1
]}

ENGBERG, G ^{[1
]}

机构：

[1] GOTHENBURG UNIV,DEPT PHARMACOL,POB 33031,S-40033 GOTHENBURG,SWEDEN

来源：

BRAIN RESEARCH | 1990年 / 521卷 / 1-2期

关键词：

C-afferent; Cutaneous thermal senstivity; Excitatory amino acid; Kynurenic acid; Locus ceruleus;

D O I：

10.1016/0006-8993(90)91560-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous electrophysiological experiments have shown that brain noradrenaline neurons in the locus ceruleus are activated by thermal cutaneous stimuli. In the present study of putative involvement of excitatory amino acids (EAA) in cutaneous LC activation was analyzed. Intraventricular administration of kynurenic acid (1 μmol), a broad spectrum EAA antagonist, or the non-NMDA antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; 0.1 μmol) as well as subcutaneous administration of the specific NMDA antagonist MK 801 (2 mg/kg) almost totally abolished the response of LC neurons to both non-noxious and noxious cutaneous sensory stimuli. We propose that the activation of LC neurons following thermal cutaneous stimuli is mediated via release of EAA from nerve terminals emanating from nucleus paragigantocellularis (PGi). © 1990.

引用

页码：325 / 328

页数：4

共 30 条

[1] EVIDENCE FOR NOREPINEPHRINE-MEDIATED COLLATERAL INHIBITION OF LOCUS COERULEUS NEURONS [J].

AGHAJANIAN, GK ;

CEDARBAUM, JM ;

WANG, RY .

BRAIN RESEARCH, 1977, 136 (03) :570-577

[2] THE BRAIN NUCLEUS LOCUS-COERULEUS - RESTRICTED AFFERENT CONTROL OF A BROAD EFFERENT NETWORK [J].

ASTONJONES, G ;

ENNIS, M ;

PIERIBONE, VA ;

NICKELL, WT ;

SHIPLEY, MT .

SCIENCE, 1986, 234 (4777) :734-737

[3]

ASTONJONES G, 1985, PHYSIOL PSYCHOL, V13, P118

[4] ENDOGENOUS PAIN CONTROL-SYSTEMS - BRAIN-STEM SPINAL PATHWAYS AND ENDORPHIN CIRCUITRY [J].

BASBAUM, AI ;

FIELDS, HL .

ANNUAL REVIEW OF NEUROSCIENCE, 1984, 7 :309-338

[5] 6,7-DINITRO-QUINOXALINE-2,3-DION AND 6-NITRO,7-CYANO-QUINOXALINE-2,3-DION ANTAGONIZE RESPONSES TO NMDA IN THE RAT SPINAL-CORD VIA AN ACTION AT THE STRYCHNINE-INSENSITIVE GLYCINE RECEPTOR [J].

BIRCH, PJ ;

GROSSMAN, CJ ;

HAYES, AG .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 156 (01) :177-180

[6]

BRIDGES RJ, 1989, J NEUROSCI, V9, P2073

[7] THE RAT NUCLEUS PARAGIGANTOCELLULARIS AS A RELAY STATION TO MEDIATE PERIPHERALLY INDUCED CENTRAL EFFECTS OF NICOTINE [J].

CHEN, Z ;

ENGBERG, G .

NEUROSCIENCE LETTERS, 1989, 101 (01) :67-71

[8] LOCUS-COERULEUS NEURONS AND SYMPATHETIC-NERVES - ACTIVATION BY CUTANEOUS SENSORY AFFERENTS [J].

ELAM, M ;

SVENSSON, TH ;

THOREN, P .

BRAIN RESEARCH, 1986, 366 (1-2) :254-261

[9] A SYNTHETIC PEPTIDE AS AN ANTAGONIST OF SUBSTANCE-P [J].

ENGBERG, G ;

SVENSSON, TH ;

ROSELL, S ;

FOLKERS, K .

NATURE, 1981, 293 (5829) :222-223

[10] NICOTINE INDUCED EXCITATION OF LOCUS COERULEUS NEURONS IS MEDIATED VIA RELEASE OF EXCITATORY AMINO-ACIDS [J].

ENGBERG, G .

LIFE SCIENCES, 1989, 44 (21) :1535-1540

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