INVOLVEMENT OF HYPOTHALAMIC SEROTONIN IN ACTIVATION OF THE SYMPATHOADRENOMEDULLARY SYSTEM AND HYPOTHALAMO-PITUITARY-ADRENOCORTICAL AXIS IN MALE WISTAR RATS

被引：66

作者：

KORTE, SM

VANDUIN, S

BOUWS, GAH

KOOLHAAS, JM

BOHUS, B

机构：

[1] Department of Animal Physiology, University of Groningen, Centre for Behavioural, 9750 AA Haren, Cognitive and Neuro-Sciences

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 197卷 / 2-3期

关键词：

5-HT1A RECEPTORS; PARAVENTRICULAR NUCLEUS; ADRENALINE; CORTICOSTERONE;

D O I：

10.1016/0014-2999(91)90527-W

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Infusion of the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (2.5-20-mu-g in 1-mu-l during 15 min), into the paraventricular nucleus of the hypothalamus (PVN) in the rat dose dependently increased plasma adrenaline and corticosterone concentrations, without affecting plasma noradrenaline concentrations. The highest dose also increased plasma glucose levels significantly. The results suggest that both the sympathoadrenomedullary system and the hypothalamo-pituitary-adrenocortical axis are activated after stimulation of 5-HT1A receptors in the PVN.

引用

页码：225 / 228

页数：4

共 15 条

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