BETA-ENDORPHIN-LIKE IMMUNOREACTIVITY IN CEREBROSPINAL-FLUID OF PATIENTS WITH ALZHEIMERS-DISEASE AND PARKINSONS-DISEASE

被引：31

作者：

JOLKKONEN, JT ^{[1
]}

SOININEN, HS ^{[1
]}

RIEKKINEN, PJ ^{[1
]}

机构：

[1] UNIV KUOPIO, DEPT NEUROL, POB 6, SF-70211 KUOPIO, FINLAND

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1987年 / 77卷 / 2-3期

关键词：

D O I：

10.1016/0022-510X(87)90118-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

.beta.-Endorphin-like immunoreactivity (.beta.-EP-LI) in cerebrospinal (CSF) was measured in 42 patients with Alzheimer''s disease (AD), 36 patients with Parkinson''s disease (PD) and 35 controls. Values for patients with Alzheimer''s disease (10.9 .+-. 2.8 pmol/l) seemed to be lower than those for controls (12.9 .+-. 2.5 pmol/l) (P < 0.05). In addition, the severely demented patients had lower values than the moderately demented (P < 0.01). In patients with Parkinson''s disease no significant difference in .beta.-EP-LI values was observed compared to the controls. The data suggest, that processing of pro-opiomelanocortin, precursor of .beta.-endorphin, and the mechanism of cognitive impairment may differ in Alzheimer''s disease and Parkinson''s disease.

引用

页码：153 / 159

页数：7

共 26 条

[1] PEPTIDES AND PARKINSONS-DISEASE
AGID, Y
JAVOYAGID, F
[J]. TRENDS IN NEUROSCIENCES, 1985, 8 (01) : 30 - 35
[2] AGE-DEPENDENT CHANGES IN THE BETA-ENDORPHIN CONTENT OF DISCRETE RAT-BRAIN NUCLEI
BARDEN, N
DUPONT, A
LABRIE, F
MERAND, Y
ROULEAU, D
VAUDRY, H
BOISSIER, JR
[J]. BRAIN RESEARCH, 1981, 208 (01) : 209 - 212
[3] CRISTENSEN AL, 1974, LURIAS NEUROPSYCHOLO
[4] DUBOIS B, 1983, BRAIN RES, V288, P213
[5] LOW CEREBROSPINAL-FLUID SOMATOSTATIN IN PARKINSON DISEASE - AN IRREVERSIBLE ABNORMALITY
DUPONT, E
CHRISTENSEN, SE
HANSEN, AP
OLIVARIUS, BD
ORSKOV, H
[J]. NEUROLOGY, 1982, 32 (03) : 312 - 314
[6] SOMATOSTATIN AND DEMENTIA IN PARKINSONS-DISEASE
EPELBAUM, J
RUBERG, M
MOYSE, E
JAVOYAGID, F
DUBOIS, B
AGID, Y
[J]. BRAIN RESEARCH, 1983, 278 (1-2) : 376 - 379
[7] CENTRAL ACTH DEFICIT IN DEGENERATIVE AND VASCULAR DEMENTIA
FACCHINETTI, F
NAPPI, G
PETRAGLIA, F
MARTIGNONI, E
SINFORIANI, E
GENAZZANI, AR
[J]. LIFE SCIENCES, 1984, 35 (16) : 1691 - 1697
[8] FACCHINETTI F, 1985, Journal of Neurochemistry, V44, pS192
[9] PARKINSONISM - ONSET PROGRESSION AND MORTALITY
HOEHN, MM
YAHR, MD
[J]. NEUROLOGY, 1967, 17 (05) : 427 - &
[10] HORNYKIEWICZ O, 1982, MOVEMENT DISORD, P41

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