SYNTHESIS OF 5-CYANO-L-TRYPTOPHAN

被引：16

作者：

DUA, RK

PHILLIPS, RS

机构：

[1] UNIV GEORGIA,DEPT CHEM,ATHENS,GA 30602

[2] UNIV GEORGIA,DEPT BIOCHEM,ATHENS,GA 30602

[3] UNIV GEORGIA,COLL PHARM,DEPT MED CHEM & PHARMACOGNOSY,ATHENS,GA 30602

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 01期

关键词：

D O I：

10.1016/S0040-4039(00)77665-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 5-bromo derivative 2 of the cyclic tautomer of N(b)-methoxycarbonyl-L-tryptophan methyl ester 1 undergoes reaction with CuCN in refluxing N-methylpyrrolidone (NMP) to give 5-cyano derivative 3a with some ring opened 5-cyano product 3b. Both 3a and 3b can be converted, in high yield, into free 5-cyano-L-tryptophan 4 with BBr3 under mild conditions.

引用

页码：29 / 32

页数：4

共 6 条

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