THE EFFECT OF GONADOTROPIN-RELEASING-HORMONE (GNRH) AGONIST IN THE FOLLICULAR PHASE ON INVITRO FERTILIZATION OUTCOME IN NORMOOVULATORY WOMEN

被引：32

作者：

SMITZ, J

VANDENABBEEL, E

BOLLEN, N

CAMUS, M

DEVROEY, P

TOURNAYE, H

VANSTEIRTEGHEM, AC

机构：

[1] Centre for Reproductive Medicine, Vrije Universiteit Brussel, B-1090 Brussels

来源：

HUMAN REPRODUCTION | 1992年 / 7卷 / 08期

关键词：

EMBRYO QUALITY; FOLLICULAR GROWTH; GNRH AGONISTS; IVF;

D O I：

10.1093/oxfordjournals.humrep.a137800

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Sixty-three normo-ovulatory infertile women were randomly divided into two groups. All women were first desensitized with the gonadotrophin-releasing hormone agonist (GnRHa), buserelin. Thereafter, ovarian stimulation with human menopausal gonadotrophins (HMG) was started in both groups but in group A the GnRHa was stopped on the same day. In group B, the GnRHa was continued during HMG treatment until the ovulatory human chorionic gonadotrophin stimulus was given. Premature luteinization was not observed in either group, although the preovulatory basal luteinizing hormone (LH) secretion was significantly higher in group A. An equal number of embryos of comparable quality was transferred in both groups and the pregnancy outcome was similar. However, the supernumerary embryos of group A were of a lower morphological quality and survived the cryopreservation process less well. We concluded that the continuous administration of a GnRH agonist during HMG treatment resulted in better quality of supernumerary embryos.

引用

页码：1098 / 1102

页数：5

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