FREE-RADICALS AND THE HEART

被引：187

作者：

KAUL, N

SIVESKIILISKOVIC, N

HILL, M

SLEZAK, J

SINGAL, PK

机构：

[1] UNIV MANITOBA, ST BONIFACE GEN HOSP,RES CTR,DIV CARDIOVASC SCI, 351 TACHE AVE, WINNIPEG R2H 2A6, MB, CANADA

[2] UNIV MANITOBA, FAC MED, DEPT PHYSIOL, WINNIPEG R3T 2N2, MANITOBA, CANADA

[3] SLOVAK ACAD SCI, INST HEART RES, CS-80936 BRATISLAVA, CZECHOSLOVAKIA

来源：

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS | 1993年 / 30卷 / 02期

基金：

英国医学研究理事会;

关键词：

OXIDATIVE STRESS; CARDIAC PATHOLOGIES; ANTIOXIDANTS; MYOCARDIAL DYSFUNCTION;

D O I：

10.1016/1056-8719(93)90008-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Because of the molecular configuration, most free radicals are highly reactive and can cause cell injury. Protective mechanisms have evolved to provide defense against free-radical injury. Any time these defense systems are overwhelmed, such as during disease states, cell dysfunction may occur. In this review we discuss cellular sources as well as the significance of free radicals, oxidative stress, and antioxidants. A probable role of oxidative stress in various cardiac pathologies has been also analyzed. Although some methods for the detection of free radicals as well as oxidative stress have been cited, better methods to study the quantity as well as subcellular distribution of free radicals are needed in order to understand fully the role of free radicals in both health and disease.

引用

页码：55 / 67

页数：13

共 185 条

[1] REDUCTION IN EXPERIMENTAL INFARCT SIZE BY RECOMBINANT HUMAN SUPEROXIDE-DISMUTASE - INSIGHTS INTO THE PATHOPHYSIOLOGY OF REPERFUSION INJURY [J].