CERAMIDE INHIBITS PANCREATIC BETA-CELL INSULIN PRODUCTION AND MITOGENESIS AND MIMICS THE ACTIONS OF INTERLEUKIN-1-BETA

被引：68

作者：

SJOHOLM, A

机构：

来源：

FEBS LETTERS | 1995年 / 367卷 / 03期

关键词：

CERAMIDE; SPHINGOLIPID; IL-1-BETA; INSULIN SECRETION; ISLET;

D O I：

10.1016/0014-5793(95)00470-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ceramide, generated during sphingomyelinase-induced sphingolipid cleavage, is considered an important mediator in cytokine signaling. The effects of endogenously generated and exogenously delivered ceramide on long-term insulin secretion and replication by pancreatic beta-cells were investigated, and compared to the effects of interleukin 1 beta (IL-1 beta). Generation of beta-cell ceramide by exogenous sphingomyelinase, or addition of cell-permeant ceramide analogs C-2-ceramide and C-6-ceramide, caused inhibitory effects on beta-cell insulin production and mitogenesis mimicing those evoked by IL-1 beta. Hence, ceramide may be involved in transducing the cytostatic and cytotoxic actions of IL-1 beta in the beta-cell.

引用

页码：283 / 286

页数：4

共 32 条

[1] ACTIVATION OF PROTEIN-KINASES AND INHIBITION OF PROTEIN PHOSPHATASES PLAY A CENTRAL ROLE IN THE REGULATION OF EXOCYTOSIS IN MOUSE PANCREATIC BETA-CELLS [J].