THE EFFECTS OF YOHIMBINE AND NEUROLEPTICS ON APOMORPHINE-INDUCED PECKING BEHAVIOR IN THE PIGEON

被引：7

作者：

AKBAS, O ^{[1
]}

VERIMER, T ^{[1
]}

ONUR, R ^{[1
]}

KAYAALP, SO ^{[1
]}

机构：

[1] HACETTEPE UNIV, SCH MED, DEPT PHARMACOL, ANKARA, TURKEY

来源：

NEUROPHARMACOLOGY | 1984年 / 23卷 / 11期

关键词：

D O I：

10.1016/0028-3908(84)90042-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of yohimbine and some neuroleptics were investigated on pecking behavior induced by apomorphine. The total pecking counts, recorded for 18 min, elicited by a standard dose of apomorphine (1 mg/kg) were inhibited dose-dependently by yohimbine and the neuroleptics. Haloperidol was the most potent, and trifluoperazine, yohimbine, chlorpromazine and the atypical neuroleptics were less effective in decreasing order. Chronic treatment with yohimbine (2.5 mg/kg per day for 20 days) caused an increase in pecking behavior. Apomorphine-induced pecking behavior in the pigeon may be used as a reliable method for screening neuroleptic drugs and the antidopaminergic activity of yohimbine is verified in this model.

引用

页码：1261 / 1264

页数：4

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