RESPONSES OF SUBSTANTIA-NIGRA PARS RETICULATA AND GLOBUS-PALLIDUS COMPLEX TO HIGH-FREQUENCY STIMULATION OF THE SUBTHALAMIC NUCLEUS IN RATS - ELECTROPHYSIOLOGICAL DATA

被引：284

作者：

BENAZZOUZ, A

PIALLAT, B

POLLAK, P

BENABID, AL

机构：

[1] Laboratoire de Neurobiophysique, UJFG, INSERM U.318, 38043 Grenoble cedex

来源：

NEUROSCIENCE LETTERS | 1995年 / 189卷 / 02期

关键词：

EXTRACELLULAR RECORDING; HIGH FREQUENCY STIMULATION; SUBTHALAMIC NUCLEUS; SUBSTANTIA NIGRA; ENTOPEDUNCULAR NUCLEUS; RATS;

D O I：

10.1016/0304-3940(95)11455-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

High frequency stimulation of the subthalamic nucleus (STN-HFS) has been shown to reverse parkinsonian motor symptoms in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys. We have studied the effect of STN-HFS on the spontaneous activity of the substantia nigra pars reticulata (SNr), entopeduncular nucleus (EP) and globus pallidus (GP) in rats. STN-HFS induced a decrease in activity of 91% of SN; cells, a suppression of activity in 80% of EP cells and an activation of 100% of GP recorded cells. These results show that STN-HFS exerts an inhibitory influence on the basal ganglia output structures similar to that obtained by STN lesion.

引用

页码：77 / 80

页数：4

共 15 条

[1] LESION OF THE SUBTHALAMIC NUCLEUS FOR THE ALLEVIATION OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE (MPTP)-INDUCED PARKINSONISM IN THE PRIMATE
AZIZ, TZ
PEGGS, D
SAMBROOK, MA
CROSSMAN, AR
[J]. MOVEMENT DISORDERS, 1991, 6 (04) : 288 - 292
[2] LONG-TERM SUPPRESSION OF TREMOR BY CHRONIC STIMULATION OF THE VENTRAL INTERMEDIATE THALAMIC NUCLEUS
BENABID, AL
POLLAK, P
GERVASON, C
HOFFMANN, D
GAO, DM
HOMMEL, M
PERRET, JE
DEROUGEMONT, J
[J]. LANCET, 1991, 337 (8738) : 403 - 406
[3] BENABID AL, 1987, APPL NEUROPHYSIOL, V50, P344
[4] REVERSAL OF RIGIDITY AND IMPROVEMENT IN MOTOR-PERFORMANCE BY SUBTHALAMIC HIGH-FREQUENCY STIMULATION IN MPTP-TREATED MONKEYS
BENAZZOUZ, A
GROSS, C
FEGER, J
BORAUD, T
BIOULAC, B
[J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 1993, 5 (04) : 382 - 389
[5] BERGMAN H, 1990, SCIENCE, V249, P1346
[6] EXCITOTOXIC ACID LESIONS OF THE PRIMATE SUBTHALAMIC NUCLEUS RESULT IN REDUCED PALLIDAL NEURONAL-ACTIVITY DURING ACTIVE HOLDING
HAMADA, I
DELONG, MR
[J]. JOURNAL OF NEUROPHYSIOLOGY, 1992, 68 (05) : 1859 - 1866
[7] INTRACELLULAR LABELING OF RAT SUBTHALAMIC NEURONS WITH HORSERADISH-PEROXIDASE - COMPUTER-ANALYSIS OF DENDRITES AND CHARACTERIZATION OF AXON ARBORIZATION
HAMMOND, C
YELNIK, J
[J]. NEUROSCIENCE, 1983, 8 (04) : 781 - &
[8] BRANCHED OUTPUT NEURONS OF THE RAT SUBTHALAMIC NUCLEUS - ELECTRO-PHYSIOLOGICAL STUDY OF THE SYNAPTIC EFFECTS ON IDENTIFIED CELLS IN THE 2 MAIN TARGET NUCLEI, THE ENTOPEDUNCULAR NUCLEUS AND THE SUBSTANTIA-NIGRA
HAMMOND, C
SHIBAZAKI, T
ROUZAIREDUBOIS, B
[J]. NEUROSCIENCE, 1983, 9 (03) : 511 - 520
[9] MILLER WC, 1987, ADV BEHAV BIOL, V32, P415
[10] NEURAL MECHANISMS UNDERLYING PARKINSONIAN SYMPTOMS BASED UPON REGIONAL UPTAKE OF 2-DEOXYGLUCOSE IN MONKEYS EXPOSED TO 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE
MITCHELL, IJ
CLARKE, CE
BOYCE, S
ROBERTSON, RG
PEGGS, D
SAMBROOK, MA
CROSSMAN, AR
[J]. NEUROSCIENCE, 1989, 32 (01) : 213 - 226

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