ANGIOTENSIN-CONVERTING ENZYME POLYMORPHISM AND DEVELOPMENT OF DIABETIC NEPHROPATHY IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS

被引：69

作者：

MIZUIRI, S ^{[1
]}

HEMMI, H ^{[1
]}

INOUE, A ^{[1
]}

YOSHIKAWA, H ^{[1
]}

TANEGASHIMA, M ^{[1
]}

FUSHIMI, T ^{[1
]}

ISHIGAMI, M ^{[1
]}

AMAGASAKI, Y ^{[1
]}

OHARA, T ^{[1
]}

SHIMATAKE, H ^{[1
]}

HASEGAWA, A ^{[1
]}

机构：

[1] TOHO UNIV,SCH MED,DEPT MOLEC BIOL,TOKYO 143,JAPAN

来源：

NEPHRON | 1995年 / 70卷 / 04期

关键词：

ANGIOTENSIN-CONVERTING ENZYME; GENE; POLYMORPHISM; DIABETES MELLITUS; NON-INSULIN-DEPENDENT; NEPHROPATHY; DIABETIC;

D O I：

10.1159/000188645

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We determined the distribution frequency of angiotensin-converting enzyme insertion/deletion (I/D) polymorphism in 111 Japanese patients with noninsulin-dependent diabetes mellitus (NIDDM) of at least 10 years duration (80 patients with diabetic nephropathy and 31 patients without nephropathy) and 76 healthy Japanese controls. Patients with diabetic nephropathy showed an excess of the ID genotype compared with patients without nephropathy (p < 0.02) and less of the II genotype compared with healthy controls (p < 0.01) and patients without nephropathy (p < 0.01). NIDDM patients with the II genotype have a decreased risk for the development of diabetic nephropathy.

引用

页码：455 / 459

页数：5

共 27 条

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