CUTANEOUS REACTIONS TO RECOMBINANT CYTOKINE THERAPY

被引:72
作者
ASNIS, LA
GASPARI, AA
机构
[1] UNIV ROCHESTER, SCH MED & DENT, DEPT MED, ROCHESTER, NY 14642 USA
[2] UNIV ROCHESTER, SCH MED & DENT, DEPT DERMATOL, ROCHESTER, NY 14642 USA
[3] UNIV ROCHESTER, SCH MED & DENT, STRONG CHILDRENS RES CTR, ROCHESTER, NY 14642 USA
[4] UNIV ROCHESTER, SCH MED & DENT, CTR CANC, ROCHESTER, NY 14642 USA
关键词
D O I
10.1016/0190-9622(95)91382-3
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Cytokines are critical to several fundamental homeostatic mechanisms such as fever, acute phase reactions, wound healing, hematopoiesis, inflammation, cellular and humoral immune responses, and tumor regression. As a result of advances in recombinant DNA technology, recombinant cytokines are available as therapeutic agents. They have been used for metastatic cancers and immunodeficiencies, as a therapy for naturally occurring or drug-induced anemias or leukopenias, and they have also been applied to some cutaneous disorders. Cytokine therapy can result in toxic reactions that affect many organ systems, especially the skin. These reactions are common and diverse, ranging from minor injection site reactions, pruritus, and flushing to life-threatening autoimmune disorders, severe erythroderma, or bullous skin reactions. This review focuses on the major cytokines that are in current clinical use or under investigation and describes the cutaneous complications of these agents.
引用
收藏
页码:393 / 410
页数:18
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