REQUIREMENT OF MIP-1-ALPHA FOR AN INFLAMMATORY RESPONSE TO VIRAL-INFECTION

被引：528

作者：

COOK, DN

BECK, MA

COFFMAN, TM

KIRBY, SL

SHERIDAN, JF

PRAGNELL, IB

SMITHIES, O

机构：

[1] UNIV N CAROLINA, DEPT PEDIAT, CHAPEL HILL, NC 27599 USA

[2] VET AFFAIRS MED CTR, DEPT INTERNAL MED, DURHAM, NC 27710 USA

[3] UNIV N CAROLINA, DEPT MED, CHAPEL HILL, NC 27599 USA

[4] OHIO STATE UNIV, HLTH SCI CTR, DEPT ORAL BIOL, COLUMBUS, OH 43210 USA

[5] OHIO STATE UNIV, HLTH SCI CTR, DEPT MED MICROBIOL & IMMUNOL, COLUMBUS, OH 43210 USA

[6] CRC, BEATSON LABS, GLASGOW G61 1BD, LANARK, SCOTLAND

来源：

SCIENCE | 1995年 / 269卷 / 5230期

关键词：

D O I：

10.1126/science.7667639

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Macrophage inflammatory protein-1 alpha (MIP-1 alpha) is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. Its biologic role in vivo was examined in mice in which the gene encoding MIP-1 alpha had been disrupted. Homozygous MIP-1 alpha mutant (-/-) mice were resistant to Coxsackievirus-induced myocarditis seen in infected wildtype (+/+) mice. Influenza virus-infected -/- mice had reduced pneumonitis and delayed clearance of the virus compared with infected +/+ mice. The -/- mice had no overt hematopoietic abnormalities. These results demonstrate that MIP-1 alpha is an important mediator of virus-induced inflammation in vivo.

引用

页码：1583 / 1585

页数：3

共 17 条

[1] VITAMIN-E-DEFICIENCY INTENSIFIES THE MYOCARDIAL INJURY OF COXSACKIEVIRUS B3 INFECTION OF MICE [J].