EXTRACELLULAR NEUROFIBRILLARY TANGLES REFLECT NEURONAL LOSS AND PROVIDE FURTHER EVIDENCE OF EXTENSIVE PROTEIN CROSS-LINKING IN ALZHEIMER-DISEASE

被引：1

作者：

CRAS, P ^{[1
]}

SMITH, MA ^{[1
]}

RICHEY, PL ^{[1
]}

SIEDLAK, SL ^{[1
]}

MULVIHILL, P ^{[1
]}

PERRY, G ^{[1
]}

机构：

[1] CASE WESTERN RESERVE UNIV,INST PATHOL,DIV NEUROPATHOL,CLEVELAND,OH 44106

来源：

ACTA NEUROPATHOLOGICA | 1995年 / 89卷 / 04期

关键词：

EXTRACELLULAR NEUROFIBRILLARY TANGLE; PROTEIN CROSS-LINKING; MICROGLIA; PROTEASE;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In this report we quantitatively assess the numbers of intracellular and extracellular neurofibrillary tangles (NFT) in the brains of a series of individuals with Alzheimer's disease and of controls and correlate these with neuronal loss. Our data indicate that in some cases, NFT are not removed from the brain throughout the disease process. This finding, together with our previous demonstration of carbonyl-related modifications in NFT, provides additional evidence that the protein constituents of NFT are resistant to proteolytic removal, possibly as a result of extensive cross-links. Additionally, con-elation between the number of NFT and neuronal loss indicates that there are at least two distinct mechanisms responsible for neuronal death in Alzheimer's disease that are directly and indirectly related to the presence of neurofibrillary pathology.

引用

页码：291 / 295

页数：5

共 27 条

[1] ESTIMATION OF NUCLEAR POPULATION FROM MICROTOME SECTIONS [J].

ABERCROMBIE, M .

ANATOMICAL RECORD, 1946, 94 (02) :239-247

[2] ASSOCIATION BETWEEN QUANTITATIVE MEASURES OF DEMENTIA AND OF SENILE CHANGE IN CEREBRAL GREY MATTER OF ELDERLY SUBJECTS [J].

BLESSED, G ;

TOMLINSON, BE ;

ROTH, M .

BRITISH JOURNAL OF PSYCHIATRY, 1968, 114 (512) :797-+

[3] ON AREAS OF TRANSITION BETWEEN ENTORHINAL ALLOCORTEX AND TEMPORAL ISOCORTEX IN THE HUMAN-BRAIN - NORMAL MORPHOLOGY AND LAMINA-SPECIFIC PATHOLOGY IN ALZHEIMERS-DISEASE [J].

BRAAK, H ;

BRAAK, E .

ACTA NEUROPATHOLOGICA, 1985, 68 (04) :325-332

[4]

Braak H., 1980, STUDIES BRAIN FUNCTI, V4, P1

[5]

BRION JP, 1985, J SUBMICR CYTOL PATH, V17, P89

[6]

GALLOWAY PG, 1990, AM J PATHOL, V137, P291

[7] ABNORMAL PHOSPHORYLATION OF THE MICROTUBULE-ASSOCIATED PROTEIN-TAU (TAU) IN ALZHEIMER CYTOSKELETAL PATHOLOGY [J].

GRUNDKEIQBAL, I ;

IQBAL, K ;

TUNG, YC ;

QUINLAN, M ;

WISNIEWSKI, HM ;

BINDER, LI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (13) :4913-4917

[8] MICROTUBULE-ASSOCIATED PROTEIN TAU (TAU) IS A MAJOR ANTIGENIC COMPONENT OF PAIRED HELICAL FILAMENTS IN ALZHEIMER-DISEASE [J].

KOSIK, KS ;

JOACHIM, CL ;

SELKOE, DJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (11) :4044-4048

[9] THE PROGRESSION OF THE PATHOLOGICAL-CHANGES OF ALZHEIMERS-DISEASE IN FRONTAL AND TEMPORAL NEOCORTEX EXAMINED BOTH AT BIOPSY AND AT AUTOPSY [J].

MANN, DMA ;

MARCYNIUK, B ;

YATES, PO ;

NEARY, D ;

SNOWDEN, JS .

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 1988, 14 (03) :177-195

[10] CORRELATION BETWEEN SENILE PLAQUE AND NEUROFIBRILLARY TANGLE COUNTS IN CEREBRAL-CORTEX AND NEURONAL COUNTS IN CORTEX AND SUBCORTICAL STRUCTURES IN ALZHEIMERS-DISEASE [J].

MANN, DMA ;

YATES, PO ;

MARCYNIUK, B .

NEUROSCIENCE LETTERS, 1985, 56 (01) :51-55

← 1 2 3 →