NEW METHODS TO PREDICT MHC-BINDING SEQUENCES WITHIN PROTEIN ANTIGENS

被引：39

作者：

HAMMER, J

机构：

[1] Roche Milano Ricerche, I-20132 Milano

来源：

CURRENT OPINION IN IMMUNOLOGY | 1995年 / 7卷 / 02期

关键词：

D O I：

10.1016/0952-7915(95)80013-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The identification and analysis of MHC-binding sequences within protein antigens, and ultimately the ability to predict them, is central to immunology. Recent advances have revealed increasingly complex MHC-binding motifs and allow prediction of sequences that bind to both classes of MHC molecules. The systematic characterization of binding motifs for all human MHC alleles is now possible and will facilitate the design of peptides for therapeutic intervention.

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页码：263 / 269

页数：7

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