A COMPARISON OF 2 DOSES OF TAMOXIFEN (NOLVADEX) IN POSTMENOPAUSAL WOMEN WITH ADVANCED BREAST-CANCER - 10 MG BD VERSUS 20 MG BD

被引：79

作者：

BRATHERTON, DG ^{[1
]}

BROWN, CH ^{[1
]}

BUCHANAN, R ^{[1
]}

HALL, V ^{[1
]}

PILLERS, EMK ^{[1
]}

WHEELER, TK ^{[1
]}

WILLIAMS, CJ ^{[1
]}

机构：

[1] ROYAL S HANTS HOSP, SOUTHAMPTON SO9 4PE, HANTS, ENGLAND

来源：

BRITISH JOURNAL OF CANCER | 1984年 / 50卷 / 02期

关键词：

D O I：

10.1038/bjc.1984.163

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In a comparative double-blind trial involving 263 postmenopausal women with advanced breast cancer treated with tamoxifen, the mean objective tumor response rate and duration was 32% and 15 mo., respectively. No significant difference was found in clinical response and adverse effects between those randomized to 10 mg and those to 20 mg twice daily. Although the mean serum concentration of tamoxifen in the 20 mg twice daily group was significantly higher, no correlation between serum level and clinical benefit was demonstrated.

引用

页码：199 / 205

页数：7

共 19 条

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