PATIENTS WITH TYPE-1 DIABETES ADAPT ACUTELY TO SUSTAINED MILD HYPOGLYCEMIA

被引：36

作者：

KERR, D ^{[1
]}

MACDONALD, IA ^{[1
]}

TATTERSALL, RB ^{[1
]}

机构：

[1] UNIV NOTTINGHAM HOSP,QUEENS MED CTR,DEPT MED,NOTTINGHAM NG7 2UH,ENGLAND

来源：

DIABETIC MEDICINE | 1991年 / 8卷 / 02期

关键词：

COUNTERREGULATION; HYPOGLYCEMIA; CATECHOLAMINES; GLUCAGON HYPOGLYCEMIA UNAWARENESS;

D O I：

10.1111/j.1464-5491.1991.tb01557.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The relationship between awareness of, and the catecholamine response to, sustained mild hypoglycaemia was examined in six well-controlled Type 1 diabetic patients (age 24-41 years, HbA1 < 10.0 %) using a hyperinsulinaemic clamp. Blood glucose was maintained at 2.8 mmol l-1 for 90 min with a euglycaemic (4.5 mmol l-1) clamp as a control. After 40 min at a blood glucose of 2.8 mmol l-1, symptom score had increased from 0.2 +/- 0.2 (+/- SE) to 3.0 +/- 0.8 (p < 0.01), cognitive function (measured by reaction time) deteriorated by 55 +/- 20 ms, and four patients 'felt hypoglycaemic'. This was associated with a rise in plasma adrenaline from 0.48 to 1.30 nmol l-1 (p < 0.01). However when hypoglycaemia was prolonged to 90 min, symptom score decreased to 1.8 +/- 0.2, none 'felt hypoglycaemic', and reaction time improved by 30 +/- 12 ms, despite a progressive rise in plasma adrenaline to 1.62 nmol l-1. Thus, despite high levels of adrenaline, diabetic patients develop reduced symptoms and no longer 'feel hypoglycaemic' during sustained mild hypoglycaemia.

引用

页码：123 / 128

页数：6

共 27 条

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