BIOLOGICAL PROPERTIES OF AUREOBASIDIN-A, A CYCLIC DEPSIPEPTIDE ANTIFUNGAL ANTIBIOTIC

被引：150

作者：

TAKESAKO, K ^{[1
]}

KURODA, H ^{[1
]}

INOUE, T ^{[1
]}

HARUNA, F ^{[1
]}

YOSHIKAWA, Y ^{[1
]}

KATO, I ^{[1
]}

UCHIDA, K ^{[1
]}

HIRATANI, T ^{[1
]}

YAMAGUCHI, H ^{[1
]}

机构：

[1] TEIKYO UNIV,SCH MED,MED MYCOL RES CTR,HACHIOJI,TOKYO 19203,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 09期

关键词：

D O I：

10.7164/antibiotics.46.1414

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aureobasidin A (AbA) is a novel cyclic depsipeptide antifungal antibiotic. The antifungal activity of AbA was studied in vitro and in vivo in comparison with clinically effective antifungal agents, amphotericin B and fluconazole. AbA was highly active in vitro against many pathogenic fungi, including Candida albicans, Cryptococcus neoformans, Blastomyces dermatitidis and Histoplasma capsulatum. The activity was superior to amphotericin B in most cases. AbA exhibited fungicidal action toward growing cultures of C. albicans. It was highly tolerated by mice and showed good efficacy in the treatment of murine systemic candidiasis when given orally or subcutaneously. AbA's fungicidal action in mice with candidiasis was more effective than fluconazole and amphotericin B.

引用

页码：1414 / 1420

页数：7

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