ASYMMETRIC TOTAL SYNTHESIS OF ISP-I (MYRIOCIN, THERMOZYMOCIDIN), A POTENT IMMUNOSUPPRESSIVE PRINCIPLE IN THE ISARIA-SINCLAIRII METABOLITE

被引:85
作者
SANO, S
KOBAYASHI, Y
KONDO, T
TAKEBAYASHI, M
MARUYAMA, S
FUJITA, T
NAGAO, Y
机构
[1] UNIV TOKUSHIMA,FAC PHARMACEUT SCI,TOKUSHIMA 770,JAPAN
[2] KYOTO PHARMACEUT UNIV,YAMASHIMA KU,KYOTO 607,JAPAN
关键词
D O I
10.1016/0040-4039(95)00219-3
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Asymmetric total synthesis of ISP-I has been achieved by utilizing highly selective E-olefin formation based on the Schlosser-modified Wittig reaction and highly diastereoselective aldol reactions employing both chiral heterocyclic derivatives, 3-acetyl-(4S)-isopropyl-1,3-thiazolidine-2-thione and ethyl [(5R)-2,5-dihydro-5-isopropyl-3,6-diethoxypyrazin]-2-yl carboxylate.
引用
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页码:2097 / 2100
页数:4
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