ASYMMETRIC TOTAL SYNTHESIS OF ISP-I (MYRIOCIN, THERMOZYMOCIDIN), A POTENT IMMUNOSUPPRESSIVE PRINCIPLE IN THE ISARIA-SINCLAIRII METABOLITE

被引：85

作者：

SANO, S

KOBAYASHI, Y

KONDO, T

TAKEBAYASHI, M

MARUYAMA, S

FUJITA, T

NAGAO, Y

机构：

[1] UNIV TOKUSHIMA,FAC PHARMACEUT SCI,TOKUSHIMA 770,JAPAN

[2] KYOTO PHARMACEUT UNIV,YAMASHIMA KU,KYOTO 607,JAPAN

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 12期

关键词：

D O I：

10.1016/0040-4039(95)00219-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric total synthesis of ISP-I has been achieved by utilizing highly selective E-olefin formation based on the Schlosser-modified Wittig reaction and highly diastereoselective aldol reactions employing both chiral heterocyclic derivatives, 3-acetyl-(4S)-isopropyl-1,3-thiazolidine-2-thione and ethyl [(5R)-2,5-dihydro-5-isopropyl-3,6-diethoxypyrazin]-2-yl carboxylate.

引用

页码：2097 / 2100

页数：4

共 18 条

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