EFFICIENT SYNTHESIS OF CARBAPENEMS VIA THE OXALIMIDE CYCLIZATION - MANIPULATION OF PROTECTING GROUPS AT THE OXALIMIDE STAGE

被引：31

作者：

KING, SA

PIPIK, B

THOMPSON, AS

DECAMP, A

VERHOEVEN, TR

机构：

[1] Department of Process Research Merck Research Laboratories Rahway

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 26期

关键词：

D O I：

10.1016/0040-4039(95)00854-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of the carbapenem nucleus from TBDMS protected acetoxyazetidinone via oxalimide cyclization technology is demonstrated. A key step is desilylation of the oxalimide intermediate. Access to a variety of protecting group schemes is demonstrated.

引用

页码：4563 / 4566

页数：4

共 16 条

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