REDUCED MICROBICIDAL AND ANTITUMOR ACTIVITIES, OF HUMAN MONOCYTES AFTER INGESTION OF PLASMODIUM-FALCIPARUM-INFECTED RED-BLOOD-CELLS

被引:47
作者
FIORI, PL
RAPPELLI, P
MIRKARIMI, SN
GINSBURG, H
CAPPUCCINELLI, P
TURRINI, F
机构
[1] HEBREW UNIV JERUSALEM, INST LIFE SCI, DEPT BIOL CHEM, IL-91904 JERUSALEM, ISRAEL
[2] UNIV SASSARI, INST MICROBIOL & VIROL, SASSARI, ITALY
[3] UNIV TURIN, DEPT GENET BIOL & MED CHEM, I-10124 TURIN, ITALY
关键词
PLASMODIUM FALCIPARUM; ESCHERICHIA COLI; STAPHYLOCOCCUS AUREUS; CANDIDA ALBICANS; MONOCYTE; PHAGOCYTOSIS; CANCER CELLS; MALARIA;
D O I
10.1111/j.1365-3024.1993.tb00579.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Oxidatively stressed red blood cells (RBC) and Plasmodium falciparum-infected RBC (PRBC) are avidly phagocytosed by human peripheral monocytes. Following the ingestion of PRBC the monocytes' ability to phagocytose PRBC and to generate aggressive oxidative compounds is severely impaired. In the present work the microbicidal and anti-tumour capacities of monocytes fed with diamide-treated RBC and PRBC harbouring mature (trophozoite) parasites have been investigated. The capacity, of the latter, but not of the former, to phagocytose Escherichia coli and Staphylococcus aureus and to kill them, as well as ingested Candida albicans cells intracellularly, was found to be markedly impaired. Monocytes that have ingested PRBC had a significantly reduced cytostatic and cytolytic activities against a lymphoblastic tumour cell line. Monocytes fed with oxidatively stressed RBC had normal or sometimes even greater anti-tumour activities. Monocytes that have ingested PRBC showed a reduced capability to produce superoxide following stimulation with phorbol ester. Such impairment in monocyte functions may explain the reduced antibacterial and anti-tumour activities of monocytes in malaria patients, and could be consequential to their ability to resist bacterial infections and to provide means for the control of tumour development in those patients.
引用
收藏
页码:647 / 655
页数:9
相关论文
共 40 条
  • [1] THE CELL BIOLOGY OF MACROPHAGE ACTIVATION
    ADAMS, DO
    HAMILTON, TA
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 1984, 2 : 283 - 318
  • [2] ENHANCING EFFECTS OF RODENT MALARIA ON AFLATOXIN B-1-INDUCED HEPATIC NEOPLASIA
    ANGSUBHAKORN, S
    SATHIROPAS, P
    BHAMARAPRAVATI, N
    [J]. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1986, 112 (02) : 177 - 179
  • [3] BEUTLER B, 1987, NEW ENGL J MED, V316, P379
  • [4] BROWN AE, 1990, CLIN EXP IMMUNOL, V82, P97, DOI 10.1111/j.1365-2249.1990.tb05410.x
  • [5] MEASUREMENT OF PHAGOCYTOSIS UTILIZING [C-14] CYANATE-LABELED HUMAN RED-CELLS AND MONOCYTES
    BUSSOLINO, F
    TURRINI, F
    ARESE, P
    [J]. BRITISH JOURNAL OF HAEMATOLOGY, 1987, 66 (02) : 271 - 274
  • [6] ROLES OF TUMOR NECROSIS FACTOR IN THE ILLNESS AND PATHOLOGY OF MALARIA
    CLARK, IA
    CHAUDHRI, G
    COWDEN, WB
    [J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1989, 83 (04) : 436 - 440
  • [7] De Weger R A, 1986, Methods Enzymol, V132, P458
  • [8] DOCKRELL HM, 1986, CLIN EXP IMMUNOL, V66, P37
  • [9] EDELSON PJ, 1982, REV INFECT DIS, V4, P124
  • [10] THE EPIDEMIOLOGY OF NON-HODGKINS LYMPHOMA IN THE NORTHEAST OF ITALY - A HOSPITAL-BASED CASE-CONTROL STUDY
    FRANCESCHI, S
    SERRAINO, D
    BIDOLI, E
    TALAMINI, R
    TIRELLI, U
    CARBONE, A
    LAVECCHIA, C
    [J]. LEUKEMIA RESEARCH, 1989, 13 (06) : 465 - 472