MODIFIED ADHERENCE OF CANDIDA-ALBICANS TO HUMAN BUCCAL EPITHELIAL-CELLS INVITRO FOLLOWING TREATMENT WITH CATIONIC, NONANTIBIOTIC ANTIMICROBIAL AGENTS

被引：7

作者：

FOWLER, S ^{[1
]}

JONES, DS ^{[1
]}

机构：

[1] UNIV OTAGO,SCH PHARM,POB 913,DUNEDIN,NEW ZEALAND

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 84卷 / 01期

关键词：

CANDIDA-ALBICANS; REDUCED ADHERENCE; CATIONIC ANTIMICROBIAL AGENT; BLASTOSPORE;

D O I：

10.1016/0378-5173(92)90217-P

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of the cationic, non-antibiotic antimicrobial agents chlorhexidine gluconate, dequalinium chloride, cetrimide and cetylpyridinium chloride on the adherence of Candida albicans blastospores (strain MEN and an oral clinical isolate, exponential and stationary growth phases) to human buccal epithelial cells in vitro were examined using light microscopy. All agents expressed significant anti-adherence activities at concentrations both greater and less than the minimum inhibitory concentration. In all cases, the anti-adherence effects were observed following treatment (30 min, 37-degrees-C) of either buccal epithelial cells or blastospores. In addition, the majority of treatments significantly increased the number of buccal epithelial cells free from adherent C. albicans. These observations may be useful in the prophylaxis of oral candidosis in prone individuals.

引用

页码：77 / 83

页数：7

共 22 条

[1] COMPARISON BETWEEN CHLORHEXIDINE AND SOME QUATERNARY AMMONIUM-COMPOUNDS WITH REGARD TO RETENTION, SALIVARY CONCENTRATION AND PLAQUE-INHIBITING EFFECT IN HUMAN MOUTH AFTER MOUTH RINSES [J].