APOLIPOPROTEIN-E EPSILON-4 ALLELE FREQUENCY IS NOT INCREASED IN PROGRESSIVE SUPRANUCLEAR PALSY

被引：41

作者：

TABATON, M

ROLLERI, M

MASTURZO, P

CAMMARATA, S

ANGELINI, G

HANSEN, LA

SAITOH, T

PETERSON, RB

PERRY, G

RICHEY, P

GAMBETTI, P

BERTOLINI, S

机构：

[1] UNIV GENOA,DEPT INTERNAL MED,CTR ATHEROSCLEROSIS PREVENT,I-16132 GENOA,ITALY

[2] NATL INST CANC RES,GENOA,ITALY

[3] CASE WESTERN RESERVE UNIV,INST PATHOL,CLEVELAND,OH 44106

[4] UNIV CALIF SAN DIEGO,DEPT NEUROCIENCIES,SAN DIEGO,CA

来源：

NEUROLOGY | 1995年 / 45卷 / 09期

关键词：

D O I：

10.1212/WNL.45.9.1764

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We examined apolipoprotein E (ApoE) immunoreactivity and allele frequency in 12 autopsied cases of progressive supranuclear palsy (PSP), a neurodegenerative disease characterized by diffuse neurofibrillary tangle (NFT) formation without beta-amyloid deposits. In spite of the ApoE immunoreactivity associated with NFTs, in PSP the ApoE allele frequency was comparable with that of age-matched normal controls. This suggests that in Alzheimer's disease the increased frequency of ApoE is an element of 4 does not influence neurofibrillary degeneration, but is probably linked to beta-amyloid deposition.

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页码：1764 / 1765

页数：2

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