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TISSUE-SPECIFIC MODULATION OF INSULIN-RECEPTOR MESSENGER-RNA LEVELS IN A PATIENT WITH A PHEOCHROMOCYTOMA

被引：4
作者：
LEAL, MA
ALLER, P
TORRES, A
PICARDO, A
CALLE, C
机构：
[1] UNIV COMPLUTENSE,FAC MED,DEPT BIOQUIM,E-28040 MADRID,SPAIN
[2] UNIV COMPLUTENSE,FAC MED,DEPT CIRUGIA,E-28040 MADRID,SPAIN
[3] CSIC,CTR INVEST BIOL,MADRID,SPAIN
来源：
CLINICAL ENDOCRINOLOGY | 1993年 / 39卷 / 05期
关键词：
D O I：
10.1111/j.1365-2265.1993.tb02418.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We have observed that the expression of the insulin-receptor gene is regulated in a tissue-specific manner in a patient with a phaeochromocytoma. Our results indicate that insulin receptor mRNA levels are decreased in adipose tissue and increased in both liver and skeletal muscle as compared with the corresponding values in the same tissues of a control patient. These findings provide the first evidence that insulin receptor mRNA levels may be modulated in vivo by high levels of catecholamines.
引用
收藏
页码：619 / 621
页数：3
相关论文
共 16 条
[1]  
ALONSO S, 1986, J MOL EVOL, V23, P1
[2]   EFFECT OF GLUCOSE ON BETA-ADRENERGIC INDUCED DOWN-REGULATION OF INSULIN-RECEPTOR BINDING IN HUMAN FAT-CELLS [J].
ARNER, P ;
HELLMER, J ;
EWERTH, S ;
OSTMAN, J .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 122 (01) :97-102
[3]   CHRONIC AND ENDOGENOUS REGULATION OF INSULIN-RECEPTORS BY CATECHOLAMINES IN ADIPOCYTES FROM PATIENTS WITH A PHEOCHROMOCYTOMA [J].
CARRANZA, MC ;
SIMON, MA ;
TORRES, A ;
CALLE, C .
BIOSCIENCE REPORTS, 1990, 10 (02) :201-207
[4]  
CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2
[5]   LONG-TERM EFFECT OF NORADRENALINE ON INSULIN BINDING TO HUMAN ADIPOSE-TISSUE INVITRO [J].
CIGOLINI, M ;
ZANCANARO, C ;
CAVALLO, E ;
BENATI, D ;
FERRARI, S ;
BOSELLO, O .
HORMONE AND METABOLIC RESEARCH, 1986, 18 (10) :718-719
[6]   MOLECULAR CHARACTERIZATION OF THE HUMAN BETA-3-ADRENERGIC RECEPTOR [J].
EMORINE, LJ ;
MARULLO, S ;
BRIENDSUTREN, MM ;
PATEY, G ;
TATE, K ;
DELAVIERKLUTCHKO, C ;
STROSBERG, AD .
SCIENCE, 1989, 245 (4922) :1118-1121
[7]  
FELDMAN JM, 1985, CURRENT DIAGNOSIS, P874
[8]   MODULATION BY DEXAMETHASONE OF INSULIN BINDING AND INSULIN-RECEPTOR MESSENGER-RNA LEVELS IN U-937 HUMAN PROMONOCYTIC CELLS [J].
LEAL, MA ;
CABANAS, C ;
RIUS, C ;
ALLER, P ;
CALLE, C .
BIOCHIMIE, 1992, 74 (06) :545-549
[9]  
LIGGETT SB, 1992, MOL PHARMACOL, V42, P634
[10]   REDUCED INSULIN BINDING TO HUMAN FAT-CELLS FOLLOWING BETA-ADRENERGIC STIMULATION - EXPERIMENTAL-EVIDENCE AND STUDIES IN PATIENTS WITH A PHEOCHROMOCYTOMA [J].
LONNROTH, P ;
WESSLAU, C ;
STENSTROM, G ;
TISELL, LE ;
SMITH, U .
DIABETOLOGIA, 1985, 28 (12) :901-906
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