THE RELEVANCE OF DRUG-DNA SEQUENCE SPECIFICITY TO ANTITUMOR-ACTIVITY

被引:22
作者
NEIDLE, S [1 ]
PUVVADA, MS [1 ]
THURSTON, DE [1 ]
机构
[1] UNIV PORTSMOUTH,SCH PHARM & BIOMED SCI,DIV MED CHEM,PORTSMOUTH PO1 2DZ,HANTS,ENGLAND
关键词
D O I
10.1016/0959-8049(94)90449-9
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:567 / 568
页数:2
相关论文
共 15 条
[1]   EFFECT OF LINKER LENGTH ON DNA-BINDING AFFINITY, CROSS-LINKING EFFICIENCY AND CYTOTOXICITY OF C8-LINKED PYRROLOBENZODIAZEPINE DIMERS [J].
BOSE, DS ;
THOMPSON, AS ;
SMELLIE, M ;
BERARDINI, MD ;
HARTLEY, JA ;
JENKINS, TC ;
NEIDLE, S ;
THURSTON, DE .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1992, (20) :1518-1520
[2]   RATIONAL DESIGN OF A HIGHLY EFFICIENT IRREVERSIBLE DNA INTERSTRAND CROSS-LINKING AGENT BASED ON THE PYRROLOBENZODIAZEPINE RING-SYSTEM [J].
BOSE, DS ;
THOMPSON, AS ;
CHING, JS ;
HARTLEY, JA ;
BERARDINI, MD ;
JENKINS, TC ;
NEIDLE, S ;
HURLEY, LH ;
THURSTON, DE .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (12) :4939-4941
[3]   SITE-SPECIFIC OLIGONUCLEOTIDE BINDING REPRESSES TRANSCRIPTION OF THE HUMAN C-MYC GENE INVITRO [J].
COONEY, M ;
CZERNUSZEWICZ, G ;
POSTEL, EH ;
FLINT, SJ ;
HOGAN, ME .
SCIENCE, 1988, 241 (4864) :456-459
[4]   DESIGN OF SEQUENCE-SPECIFIC DNA-BINDING MOLECULES [J].
DERVAN, PB .
SCIENCE, 1986, 232 (4749) :464-471
[5]   DESIGN AND BINDING OF A DISTAMYCIN-A ANALOG TO D(CGCAAGTTGGC)BULLET-D(GCCAACTTGCG) - SYNTHESIS, NMR-STUDIES, AND IMPLICATIONS FOR THE DESIGN OF SEQUENCE-SPECIFIC MINOR GROOVE BINDING OLIGOPEPTIDES [J].
DWYER, TJ ;
GEIERSTANGER, BH ;
BATHINI, Y ;
LOWN, JW ;
WEMMER, DE .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (15) :5911-5919
[6]   DNA-SEQUENCE SPECIFICITY OF ANTITUMOR AGENTS - ONCOGENES AS POSSIBLE TARGETS FOR CANCER-THERAPY [J].
HARTLEY, JA ;
LOWN, JW ;
MATTES, WB ;
KOHN, KW .
ACTA ONCOLOGICA, 1988, 27 (05) :503-510
[7]  
HELENE C, 1989, OLIGODEOXYNUCLEOTIDE
[8]   DNA AND ASSOCIATED TARGETS FOR DRUG DESIGN [J].
HURLEY, LH .
JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (09) :2027-2033
[9]   INTERACTION OF BERENIL WITH THE TYRT DNA-SEQUENCE STUDIED BY FOOTPRINTING AND MOLECULAR MODELING - IMPLICATIONS FOR THE DESIGN OF SEQUENCE-SPECIFIC DNA RECOGNITION AGENTS [J].
LAUGHTON, CA ;
JENKINS, TC ;
FOX, KR ;
NEIDLE, S .
NUCLEIC ACIDS RESEARCH, 1990, 18 (15) :4479-4488
[10]  
LI LH, 1992, CANCER RES, V52, P4904