CORTICOSTRIATAL AND THALAMIC REGULATION OF AMPHETAMINE-INDUCED ASCORBATE RELEASE IN THE NEOSTRIATUM

被引:55
作者
BASSETOMUSK, A [1 ]
REBEC, GV [1 ]
机构
[1] INDIANA UNIV,DEPT PSYCHOL,PROGRAM NEURAL SCI,BLOOMINGTON,IN 47405
基金
美国国家科学基金会;
关键词
Amphetamine; Ascorbate; Corticostriatal pathway; In vivo; Neostriatum Ventromedial thalamic nucleus; Voltammetry;
D O I
10.1016/0091-3057(90)90204-U
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Lesions of cerebral cortex and ventromedial nucleus (VM) of the thalamus were made in rats to investigate the contribution of these structures to amphetamine (AMPH)-induced ascorbate (AA) release in the neostriatum as measured by in vivo voltammetry. Following a recovery period of at least one week, rats were anesthetized, and electrochemically modified, carbon-fiber electrodes were lowered into the neostriatum. Compared to data obtained from sham-operated and unoperated controls, bilateral aspiration lesions of cerebral cortex significantly lowered both the basal level of AA and the amount of AA released by AMPH in the neostriatum. Similar results were obtained after bilateral, but not unilateral electrolytic lesions of the VM thalamus. Collectively, these results suggest the corticostriatal pathway and the VM thalamic nuclei participate in the regulation of basal and AMPH-induced AA release in the neostriatum. © 1990.
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页码:55 / 60
页数:6
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