DISTRIBUTION OF POLYMORPHIC HLA-DR AND HLA-DQ ALLELES AS DETERMINED BY RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM ANALYSIS IN AN AUSTRIAN POPULATION

被引：13

作者：

FISCHER, GF

FAE, I

PICKL, WF

机构：

[1] Institut Für Blutgruppenserologie, Universität Wien

来源：

VOX SANGUINIS | 1992年 / 62卷 / 04期

关键词：

D O I：

10.1111/j.1423-0410.1992.tb01205.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The restriction fragment length polymorphism (RFLP) of HLA-DR-beta, -DQ-alpha and -DQ-beta genes was analyzed in 637 unrelated individuals from the Austrian population. The restriction enzyme was Taq I, and three exon-specific probes were applied. The gene frequencies, the Hardy-Weinberg equilibrium in DR-beta and DQ loci. linkage disequilibria between the loci and haplotype frequencies are calculated. Rare associations between DR and DQ loci are described. Two RFLP patterns are demonstrated which were unique in the overall 1,000 individuals tested so far.

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页码：236 / 241

页数：6

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