RECONSTITUTION OF SEVERE COMBINED IMMUNODEFICIENT MICE WITH INTRATHYROIDAL LYMPHOCYTES OF THYROID XENOGRAFTS FROM PATIENTS WITH HASHIMOTO THYROIDITIS

被引:24
作者
AKASU, F
MORITA, T
RESETKOVA, E
MILLER, N
AKASU, R
JAMIESON, C
VOLPE, R
机构
[1] UNIV TORONTO, WELLESLEY HOSP,ENDOCRINOL RES LAB, 160 WELLESLEY ST E,ROOM 112D JONES BLDG, TORONTO M4Y 1J3, ONTARIO, CANADA
[2] UNIV TORONTO, WELLESLEY HOSP, DEPT MED, TORONTO M4Y 1J3, ONTARIO, CANADA
[3] UNIV TORONTO, WELLESLEY HOSP, DEPT PATHOL, TORONTO M4Y 1J3, ONTARIO, CANADA
[4] UNIV TORONTO, WELLESLEY HOSP, DEPT SURG, TORONTO M4Y 1J3, ONTARIO, CANADA
[5] UNIV TORONTO, WOMENS COLL, DEPT PATHOL, TORONTO M5S 1A1, ONTARIO, CANADA
关键词
D O I
10.1210/jc.76.1.223
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Thyroid tissues from patients with Hashimoto's thyroiditis (HT) have been xenografted to both severe combined immunodeficiency (SCID) mice and nude mice to study the intrathyroidal lymphocytes which were expected to migrate from the xenografts in the SCID mice. Peripheral blood mononuclear cells from HT, Graves' disease, and normal donors have also been separately engrafted. SCID mice, but not nude mice with HT thyroid grafts produce human immunoglobulins. More immunoglobulin G (IgG), but less IgM and IgA is produced in SCID mice with HT thyroid grafts (SCID-TH), compared to SCID mice injected with peripheral blood mononuclear cells from patients with HT or normal donors (SCID-PB), suggesting that different B cell subpopulations were active in the SCID-PB vs. SCID-TH. Production of IgG by SCID-PB and SCID-TH was maintained 6 weeks after engraftment, and decreased thereafter. SCID mice but not nude mice grafted with HT thyroid tissue produce antibodies to thyroglobulin and thyroperoxidase. Lymphocytes within intact HT thyroid grafts persist in SCID mice, and migrate to the spleen, whereas human lymphocytes do not survive in the thyroid grafts or other tissues of the nude mouse. In 6 weeks, the xenografts in nude mice became histologically normal. In contrast, xenografts from SCID mice showed more marked inflammatory changes than in the original human lesion, although the ratio of T/B cells is unchanged. This worsening of the lesion may relate to the increase in activation of the T-lymphocytes.
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页码:223 / 230
页数:8
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