THE EFFECT OF INDOMETHACIN UPON CEREBRAL BLOOD-FLOW IN HEALTHY-VOLUNTEERS - THE INFLUENCE OF MODERATE HYPOXIA AND HYPERCAPNIA

被引：30

作者：

JENSEN, K

FREUNDLICH, M

BUNEMANN, L

THERKELSEN, K

HANSEN, H

COLD, GE

机构：

[1] HJORRING MUNICIPAL HOSP,DEPT ANESTHESIOL,HJORRING,DENMARK

[2] AARHUS UNIV HOSP,DEPT ANESTHESIOL,DK-8000 AARHUS,DENMARK

来源：

ACTA NEUROCHIRURGICA | 1993年 / 124卷 / 2-4期

关键词：

ADAPTATION; CEREBRAL BLOOD FLOW; HYPERCAPNIA; HYPOXIA; INDOMETHACIN;

D O I：

10.1007/BF01401132

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In a randomized study of healthy volunteers indomethacin bolus injection followed by continuous infusion decreased CBF from normal levels ranging from 45 to 80 ml/100 g/min to levels ranging from 24 to 57 ml/100 g/min. These low levels were sustained during a six hour infusion period. Periods of hypoxia during inhalation of 17% oxygen and hypercapnia during inhalation of 2-4% CO2 normalized CBF.

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页码：114 / 119

页数：6

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