CHARACTERIZATION OF BINDING-SITES FOR A GNRH-AGONIST (BUSERELIN) IN HUMAN BREAST-CANCER BIOPSIES AND THEIR DISTRIBUTION IN RELATION TO TUMOR PARAMETERS

被引：63

作者：

BAUMANN, KH ^{[1
]}

KIESEL, L ^{[1
]}

KAUFMANN, M ^{[1
]}

BASTERT, G ^{[1
]}

RUNNEBAUM, B ^{[1
]}

机构：

[1] UNIV HEIDELBERG,DEPT NUKL MED,W-6900 HEIDELBERG,GERMANY

来源：

BREAST CANCER RESEARCH AND TREATMENT | 1993年 / 25卷 / 01期

关键词：

BREAST CANCER; GONADOTROPIN-RELEASING HORMONE-ANALOG; GNRH; RECEPTOR;

D O I：

10.1007/BF00662399

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gonadotropin-releasing hormone analogs (GnRH-A) have been added to the armentarium in the therapy of hormone-dependent breast cancer in premenopausal women. The effect of chronic GnRH-A-treatment in premenopausal women is based on the suppression of the hypothalamus-pituitary-ovarian axis and the reduction of sex-steroid serum levels. In addition, a number of experimental and clinical data have been accumulated indicating a direct action of GnRH-A on breast cancer cells and tissue. In this study we analyzed 235 human breast cancer biopsies for specific GnRH-A-binding. We demonstrate high affinity GnRH-A binding sites in human breast cancer tissues. The evaluation of clinical data showed no correlation of the level of GnRH-A-binding with classical tumor parameters.

引用

页码：37 / 46

页数：10

共 48 条

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