TRANSFORMING GROWTH-FACTOR-BETA-2 (TGF-ETA-2) IS ASSOCIATED WITH MATURE RAT NEUROMUSCULAR-JUNCTIONS

被引：31

作者：

MCLENNAN, IS

KOISHI, K

机构：

[1] Department of Anatomy and Structural Biology, University of Otago, Dunedin

来源：

NEUROSCIENCE LETTERS | 1994年 / 177卷 / 1-2期

关键词：

TGF-BETA-2; MOTONEURON; NEUROMUSCULAR JUNCTION; SCHWANN CELL; NEUROTROPHIC FACTOR; ACETYLCHOLINE RECEPTOR;

D O I：

10.1016/0304-3940(94)90889-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The localisation of transforming growth factor-beta-2 (TGF-beta 2) in skeletal muscles was investigated with immunohistochemistry. In neonates, TGF-beta 2 was distributed throughout the muscle fibres but as the fibres matured TGF-beta 2 became restricted to the circumference of a small subpopulation of nuclei. These nuclei were judged to be the subsynaptic nuclei as they lay beneath the plasmalemma and were associated with alpha-bungarotoxin-labelled neuromuscular junctions. These observations point to TGF-beta 2 being either a trophic factor for mature motoneurones or an autocrine regulator of synaptic protein production.

引用

页码：151 / 154

页数：4

共 12 条

[1] MOTONEURON SURVIVAL REQUIREMENTS DURING DEVELOPMENT - THE CHANGE FROM IMMATURE ASTROCYTE DEPENDENCE TO MYOTUBE DEPENDENCE [J].