INCREASED PLASMA TUMOR-NECROSIS-FACTOR-ALPHA CONCENTRATION IN ATOPIC-DERMATITIS

被引：66

作者：

SUMIMOTO, S ^{[1
]}

KAWAI, M ^{[1
]}

KASAJIMA, Y ^{[1
]}

HAMAMOTO, T ^{[1
]}

机构：

[1] SUMITOMO HOSP,DEPT PAEDIAT,OSAKA,JAPAN

来源：

ARCHIVES OF DISEASE IN CHILDHOOD | 1992年 / 67卷 / 03期

关键词：

D O I：

10.1136/adc.67.3.277

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Plasma tumour necrosis factor-alpha (TNF-alpha) was measured in 15 children with atopic dermatitis, 13 children with bronchial asthma, and 11 healthy controls. Plasma TNF-alpha concentration was increased in atopic dermatitis and the magnitude of the increase was correlated with the severity of the dermatitis but TNF-alpha concentration was not increased in bronchial asthma. A significant correlation was found between plasma TNF-alpha and plasma histamine concentrations in atopic dermatitis. The data suggest that the over-production of TNF-alpha is associated with increased plasma histamine concentration, and might play a part in the pathophysiological mechanism of atopic dermatitis.

引用

页码：277 / 279

页数：3

共 18 条

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