THE SYNTHESIS OF 3-TRIMETHYLSILYL-4-DIMETHYL(PHENYL)SILYLBUT-3-EN-2-ONE, A BETA-FUNCTIONALIZED MICHAEL ACCEPTOR

被引：23

作者：

FLEMING, I

NEWTON, TW

SABIN, V

ZAMMATTIO, F

机构：

[1] University Chemical Laboratory, Cambridge, CB2 1EW, Lensfield Road

来源：

TETRAHEDRON | 1992年 / 48卷 / 37期

关键词：

D O I：

10.1016/S0040-4020(01)80457-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title compound 3 has been prepared by silyl-cupration of trimethylsilylacetylene followed by acetylation. The phenyidimethylsilyl group can be removed selectively in a three-step procedure to give 3-trimethylsilylbut-3-ene-2-one lb. The enone 3 and cyclohexanone can be used in an annelation reaction to make 5-dimethyl(phenyl)silylbicyclo[4.4.0]decan-3-one 20 and hence to make 2-vinylcyclohexylacetic acid 23.

引用

页码：7793 / 7802

页数：10

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